Clinical Research Directory

Inclusion Criteria: * Written informed consent consistent with ICH-GCP and local laws, signed prior to any study procedures being performed * Age \>18 years * A clinical diagnosis of ILD with accepted specific diagnoses including: * Idiopathic pulmonary fibrosis (IPF) * Chronic hypersensitivity pneumonitis associated ILD (CHP-ILD) * Connective tissue disease associated ILD (CTD-ILD) * Pneumoconiosis * Daily Cough for at least 8 weeks * Able to produce an adequate sample with sputum induction Exclusion Criteria: * Patients with a diagnosis of systemic sclerosis associated ILD (SSc-ILD) or sarcoidosis * Cause of cough attributed to a known etiology (ex. ACE-inhibitor, uncontrolled gastroesophageal reflux or upper airway cough syndrome, acute viral illness) * Current use of inhaled corticosteroids * Current use of systemic corticosteroids (prednisone equivalent \> 20mg/day) * Current use of chronic antibiotics * Airflow obstruction (ie. pre-bronchodilator FEV1/FVC ratio \< 0.7) * History of physician-diagnosed asthma * History of emphysema * A history of cholestatic jaundice or hepatic dysfunction associated with prior use of azithromycin * Moderate to severe hepatic dysfunction with a Child Pugh score \>10 * Known allergy or hypersensitivity to inhaled corticosteroids or macrolide antibiotics * Corrected QT-interval (QTc) on screening electrocardiogram (ECG) of \> 450ms * An established history of untreated atypical mycobacterial infection * A history of hearing impairment, tinnitus, or vertigo * Medication use likely to suppress cough (ex: morphine, gabapentin, amitriptyline)