Clinical Research Directory

Inclusion Criteria: 1. Gonarthrosis grade 2, 3 or 4 of Kellgren and Lawrence (Kellgren \& Lawrence, 1957) assessed by two observers. 2. Chronic painful knee of mechanical characteristics. 3. Absence of local or systemic septic process. 4. Hemat imetric and biochemical analysis without significant alterations that contraindicate the treatment. 5. Written informed consent of the patient. 6. The patient is able to understand the nature of the study. 7. Body Mass Index 20-35 Kg/m2. Exclusion Criteria: 1. Patient \< 18 years old, or legally dependent. 2. Patient \> 75 years old. 3. Congenital or developmental diseases that translate malformation and / or significant deformations of the knee (varus\>10º; valgus\>20º) and condition difficulties of application and evaluation of the results. 4. Pregnant or breastfeeding women. 5. Neoplastic disease. 6. Intra-articular infiltration of any drug in the 3 months prior to study inclusion. 7. Concurrent participation in another clinical trial or treatment with another investigational product within 30 days prior to study enrollment. 8. Allergy to gentamicin (antibiotic used in the cell culture process ). 9. Other diseases or circumstances that compromise participation in the study according to medical criteria.