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Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations
Sponsor: University of British Columbia
Summary
This is a randomized open label study in de novo liver transplant recipients that aims to compare the risk of tacrolimus induced tremors with once daily extended-release formulation, Envarsus, versus the twice daily immediate-release formulation. Both formulations of tacrolimus are currently approved for the prevention of rejection in liver transplant patients.
Official title: Tacrolimus Associated Tremors in Liver Transplant Recipients: a Randomized Open Label Trial Comparing De Novo Extended-release Once Daily (LCP-TAC) and Twice Daily Immediate-release (IR-TAC) Tacrolimus Formulations
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2023-01-09
Completion Date
2026-12-31
Last Updated
2024-01-02
Healthy Volunteers
No
Interventions
Tacrolimus, Immediate Release, Oral
Twice Daily Tacrolimus
Tacrolimus Extended Release Oral Tablet
Once Daily Tacrolimus
Locations (1)
Vancouver General Hospital
Vancouver, British Columbia, Canada