Clinical Research Directory

Inclusion Criteria: 1. are ≥18 years of age 2. are scheduled to undergo surgery within 28 days 3. are a current smoker and not currently using any smoking cessation treatment and, 4. have a smart mobile phone with an active, up to date data plan and with internet access 5. provide informed consent to participate. Exclusion Criteria: 1. are pregnant or breastfeeding or expecting to become pregnant during the study follow-up period 2. are deemed unreliable for study procedures or follow-up 3. have a documented allergic reaction to cytisine, or its components (non-medicinal ingredients) or to the non-medicinal ingredients of the placebo. 4. had myocardial infarction, unstable angina, or stroke/transient ischemic attack within the preceding 2 weeks. 5. will have surgery with expected nil intake by mouth for 2 or more days 6. have previously participated in PREVENT 7. have a known diagnosis of untreated pheochromocytoma; Schizophrenia/bipolar psychiatric illness and currently psychotic; currently having suicidal ideation or risk of suicide as determined by the site physician, known history of moderate to severe depression; currently uncontrolled severe hypertension (≥180/120 mmHg) despite treatment; known history of uncontrolled hyperthyroidism (thyrotoxicosis), severe renal impairment i.e., creatinine clearance of less than 30 ml per minute (Cockcroft- Gault equation) or receiving long-term dialysis, or known diagnosis of severe liver disease as determined by the site physician or documented in the clinical history.