Clinical Research Directory

Inclusion Criteria: * Patients ≥ 18 years old at the time of informed consent * Ability to provide written informed consent and HIPAA authorization * Primary or recurrent invasive cutaneous squamous cell carcinoma of the head or neck, clinically staged T2-T4 based on AJCC staging * Clinically and radiographically regional node-negative (no evidence of regional lymph node metastasis or distant metastasis) * Able to undergo general anesthesia for sentinel lymph node biopsy * Able to undergo CT scan with contrast or MRI with contrast * Undergo surgical resection (Moh's or micrographic resection or standard excision with sentinel lymph node biopsy) within 8 weeks of imaging Exclusion Criteria: * Clinical evidence of satellite lesions, in-transit, regional nodal or distant metastases * Known biopsy proven synchronous primary cutaneous squamous cell carcinoma * Pregnant patients * Patients unable to undergo general anesthesia * Patient unable to receive contrasted imaging studies * Patient unable to receive and/or allergic to 99m-Technetium sulfur colloid