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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
Sponsor: University of Pennsylvania
Summary
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2021-10-07
Completion Date
2028-03-31
Last Updated
2026-02-09
Healthy Volunteers
Yes
Conditions
Interventions
Seasonal influenza vaccine
The seasonal influenza vaccine is administered intramuscularly at a dose of 15 ug of HA per component, as approved by the FDA.
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States