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Hypofractionated vs Conventional Fractionated RT in Soft Tissue Sarcomas
Sponsor: University of Wisconsin, Madison
Summary
This research study is designed to find out if radiation therapy treatment prior to surgery is safe and effective to treat soft tissue sarcomas. 30 participants with soft tissue sarcoma will be enrolled and can expect to be on study for up to 5 years.
Official title: Phase II Trial of Neoadjuvant Hypofractionated Radiotherapy Versus Conventionally Fractionated Radiotherapy for Soft Tissue Sarcomas
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2022-04-06
Completion Date
2028-11
Last Updated
2026-01-28
Healthy Volunteers
No
Conditions
Interventions
Conventional Fractionated
50 Gy in 25 fractions will be prescribed to cover 95% of the planning tumor volume (PTV). More than 99% of the PTV should receive \> 97% of the prescribed dose. For dose homogeneity, no more than 20% of the PTV will receive ≥ 110% prescription dose.
Hypofractionated
27.5 Gy in 5 fractions will be prescribed to cover 95% of the PTV. More than 99% of the PTV should receive \> 97% of the prescribed dose
Locations (1)
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States