Clinical Research Directory

Inclusion Criteria: 1. Patients with an attack of gout, diagnosed immediately or less than 5 days old. Gout is defined according to American-European criteria (Appendix 3). 2. Attack of gout affecting one (or more) peripheral joint (s) whatever (s) it (s): * Either a first crisis, * Either a new attack of a gout not treated with a hypo-uricemic or for which the hypo-uricemic treatment has not been taken for at least 6 months. 3. Uricemia ≥ 420 µmol / l, including under a diuretic (dosage carried out within 10 days before inclusion), 4. Age ≥ 18 years old, 5. Patient with a creatinine clearance ≥ 30 ml / min (dosage carried out within 10 days before inclusion), 6. Patient having read and understood the information letter and signed the consent form, 7. Affiliation to a social security scheme, 8. Woman of childbearing potential with effective contraception according to WHO definition (estrogen-progestins or intrauterine device or tubal ligation for more than 1 month and to be continued for at least 5 weeks after the last dose of the drug. ) and a negative urine pregnancy test on inclusion and throughout the duration of the study Where Postmenopausal woman: amenorrhea not medically induced for at least 12 months before the inclusion visit. Exclusion Criteria: 1. Patients under the age of 18, 2. Stop taking a hypouricemic agent for less than 6 months, 3. Known contraindication to ADENURIC 80 mg film-coated tablet: hypersensitivity to the active substance (febuxostat) or to one of the excipients, 4. Renal failure defined by creatinine clearance \<30 ml / min, 5. Hepatic disease defined by an increase to more than 2 times the normal of transaminases, alkaline phosphatases, to more than 3 times the normal of gamma-GT, 6. Non-weaned alcoholism, 7. Crisis more than 5 days old, 8. Patient who has received an organ or marrow transplant, 9. Person on Naproxen, mercaptopurine, azathioprine, Glycuronidation inhibitors and inducers, theophylline, macrolides, HMG Co-A reductase inhibitors and / or diuretic in combination with an ACE inhibitor or ARAII, 10. Person with rare hereditary disorders of galactose intolerance, lactase deficiency or glucose / galactose malabsorption 11. Poor understanding of the project due to neurological disease or lack of French practice, 12. Pregnant woman or likely to be in the absence of effective contraception (Women of childbearing age should have a negative urine pregnancy test), 13. Breastfeeding woman 14. Any history of pre-existing major cardiovascular disease (myocardial infarction, stroke, unstable angina, etc.), metabolic, endocrine, psychiatric or cancerous in uncontrolled development, 15. Person deprived of liberty by an administrative or judicial decision, 16. Person placed under judicial protection, guardianship or curatorship, 17. Participating patient who participated in the month preceding inclusion in another interventional drug trial.