Clinical Research Directory

Inclusion Criteria: * 18 years of age or older * Must provide and sign the Informed Consent prior to any study related procedures * Spinal cord injury lesion level between C3 and T6 (inclusive) * SCI ≥ 1month * Confirmed orthostatic hypotension * Stable medical, physical and psychological condition as considered by the investigators * Able to understand and interact with the study team in French or English * Agrees to comply in good faith with all conditions of the study and to attend all scheduled appointments Exclusion Criteria: * SCI related to a neurodegenerative disease * Diseases and conditions that would increase the morbidity and mortality of spinal cord injury surgery * The inability to withhold antiplatelet/anticoagulation agents perioperatively * History of myocardial infarction or cerebrovascular event within the past 6 months * Other conditions that would make the subject unable to participate in testing in the judgement of the investigators * Clinically significant mental illness in the judgement of the investigators * Botulinum toxin vesical and non-vesical injections in the previous 3 months before the enrolment * Presence of significant pressure ulcers * Recurrent urinary tract infection refractory to antibiotics * Presence of indwelling baclofen or insulin pump * Women who are pregnant (pregnancy test obligatory for woman of childbearing potential) or breast feeding, * Lack of safe contraception for women of childbearing capacity, * Intention to become pregnant during the course of the study, * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.), * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders or dementia of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Enrolment of the investigator, his/her family members, employees, and other dependent persons.