Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years old. * Known cardiac ischemia, who are non revascularizable, or have not and will not be undergo coronary intervention for the duration of their participation in the study. * Evidence of ischemia from previous clinical tests (echo, nuclear, standard ECG from past 6 months). * Left Ventricular Ejection fraction \> 40% by echo (evaluated last 3 months). * Able to complete a cardiopulmonary exercise test without significant non cardiac limitations, primarily orthopedic. * On guideline directed optimal therapy for stable ischemia. Exclusion Criteria: * Anemia (\< 7 mg/dl). * Low potassium (\< 3 mmol/L). * Creatinine (\> 5.0 mg/dl or \< 0.6 mg/dl). * Unable to exercise due primarily to orthopedic limitation. * Severe lung disease. * Morbid obesity (BMI \> 42). * Pregnant. * Breast feeding. * Significant arrhythmia (ventricular tachycardia, ventricular fibrillation, frequent premature ventricular contractions (PVCs), persistent atrial fibrillation, or 2nd or 3rd degree atrioventricular (AV) block). * Seizures. * Unstable angina. * Coronary spasm. * Recent myocardial infarction (\< 90 days). * Recent percutaneous coronary intervention (\<90 days).