Clinical Research Directory

Inclusion Criteria 1. Patients admitted to participating hospital with a clinical diagnosis of acute exacerbation of bronchiectasis (AEB), defined as a change in bronchiectasis treatment associated with deterioration in three or more of the following key symptoms for at least 48 hours: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; or haemoptysis. 2. Patients with an established diagnosis of bronchiectasis, defined as the presence of cough, shortness of breath, chronic sputum production, recurrent respiratory infection, or a combination thereof with CT thorax scan confirmation of the presence of bronchiectasis indicated by a bronchoarterial ratio of \> 1, lack of tapering, airway visibility within 1 cm of the pleural surface, or a combination thereof. Exclusion criteria 1. Patients unable to provide informed consent 2. Age \< 18 years 3. Pregnancy 4. Bronchiectasis due to known cystic fibrosis 5. Bronchiectasis is not the main or co-dominant respiratory disease 6. Traction bronchiectasis due to interstitial lung disease 7. Prior lung transplantation for bronchiectasis