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Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
Sponsor: AstraZeneca
Summary
This study will look at the efficacy and safety of trastuzumab deruxtecan (T-DXd) in a neoadjuvant setting, in high-risk, HER2-positive early non-metastatic breast cancer.
Official title: A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd Followed by THP Compared to ddAC-THP in Participants With High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast11)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
927
Start Date
2021-10-25
Completion Date
2027-04-30
Last Updated
2026-02-23
Healthy Volunteers
No
Interventions
Trastuzumab Deruxtecan
administered by intravenous infusion
Paclitaxel
administered by intravenous infusion
Trastuzumab
administered by intravenous infusion
Pertuzumab
administered by intravenous infusion
Doxorubicin
administered by intravenous infusion
cyclophosphamide
administered by intravenous infusion
Locations (145)
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Springdale, Arkansas, United States
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Beverly Hills, California, United States
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Glendale, California, United States
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Los Alamitos, California, United States
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Orange, California, United States
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New Haven, Connecticut, United States
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Fort Wayne, Indiana, United States
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Lexington, Kentucky, United States
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Louisville, Kentucky, United States
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Shreveport, Louisiana, United States
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Minneapolis, Minnesota, United States
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Las Vegas, Nevada, United States
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East Brunswick, New Jersey, United States
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Summit, New Jersey, United States
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Commack, New York, United States
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Durham, North Carolina, United States
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Greenville, South Carolina, United States
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Germantown, Tennessee, United States
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Nashville, Tennessee, United States
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Fort Worth, Texas, United States
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Ogden, Utah, United States
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Tacoma, Washington, United States
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Goiânia, Brazil
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Ijuí, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Panagyurishte, Bulgaria
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Sofia, Bulgaria
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Edmonton, Alberta, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Montreal, Canada
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Beijing, China
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Changsha, China
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Changsha, China
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Chongqing, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Kunming, China
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Nanning, China
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Qingdao, China
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Shanghai, China
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Shenyang, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Zhengzhou, China
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Augsburg, Germany
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Berlin, Germany
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Erlangen, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Kiel, Germany
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Leipzig, Germany
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Mönchengladbach, Germany
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München, Germany
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Münster, Germany
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Paderborn, Germany
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Tübingen, Germany
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Gūrgaon, India
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Howrah, India
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Nagpur, India
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Nashik, India
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New Delhi, India
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New Delhi, India
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Raipur, India
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Rishikesh, India
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Surat, India
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Thiruvananthapuram, India
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Bologna, Italy
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Candiolo, Italy
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Livorno, Italy
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Milan, Italy
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Naples, Italy
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Negrar, Italy
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Padova, Italy
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Roma, Italy
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Rozzano, Italy
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Chūōku, Japan
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Chūōku, Japan
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Hidaka-shi, Japan
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Hiroshima, Japan
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Kawasaki-shi, Japan
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Kōtoku, Japan
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Nagoya, Japan
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Nagoya, Japan
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Ota-shi, Japan
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Shinjuku-ku, Japan
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Bacolod, Philippines
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Cebu City, Philippines
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Davao City, Philippines
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Iloilo City, Philippines
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Quezon City, Philippines
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San Juan City, Philippines
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Bialystok, Poland
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Biała Podlaska, Poland
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Bydgoszcz, Poland
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Koszalin, Poland
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Lublin, Poland
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Rzeszów, Poland
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Warsaw, Poland
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Moscow, Russia
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Moscow, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Dammam, Saudi Arabia
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Jeddah, Saudi Arabia
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Jeddah, Saudi Arabia
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Riyadh, Saudi Arabia
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Riyadh, Saudi Arabia
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Goyang-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Seville, Spain
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Vigo, Spain
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan District, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Chiang Mai, Thailand
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Hat Yai, Thailand
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Khon Kaen, Thailand