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Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Sponsor: McMaster University
Summary
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.
Official title: Single Dose of Antenatal Corticosteroids (SNACS) Randomized Controlled Trial for Pregnancies at Risk of Preterm Delivery: To Keep Babies and Children Safe
Key Details
Gender
FEMALE
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
3254
Start Date
2023-07-20
Completion Date
2029-12-31
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Interventions
Celestone + placebo
After the first intramuscular injection of Celestone, participants randomized to the "Placebo Comparator" group will receive 1 intramuscular injection of placebo.
Celestone + Celestone
After the first intramuscular injection of Celestone, participants randomized to the "Active Comparator" group will receive 1 intramuscular injection of Celestone.
Locations (25)
University of Calgary, Cumming School of Medicine
Calgary, Alberta, Canada
Alberta Health Services; University of Alberta
Edmonton, Alberta, Canada
Royal Columbian Hospital
New Westminster, British Columbia, Canada
Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre
Surrey, British Columbia, Canada
University of British Columbia; BC Women's Hospital
Vancouver, British Columbia, Canada
Victoria General Hospital
Victoria, British Columbia, Canada
University of Manitoba, Health Sciences Centre
Winnipeg, Manitoba, Canada
University of Manitoba; St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Dr. Everett Chalmers Regional Hospital
Fredericton, New Brunswick, Canada
The Moncton Hospital, Horizon Health Network
Moncton, New Brunswick, Canada
Memorial University, Eastern Health
St. John's, Newfoundland and Labrador, Canada
Dalhousie University; Izaak Walton Killam Health
Halifax, Nova Scotia, Canada
McMaster University
Hamilton, Ontario, Canada
Queen's University, Kingston General Hospital Health Sciences Centre
Kingston, Ontario, Canada
Western University; London Health Sciences Centre, Victoria Hospital
London, Ontario, Canada
University of Ottawa; The Ottawa Hospital
Ottawa, Ontario, Canada
Mount Sinai Hospital
Toronto, Ontario, Canada
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada
Hopital Maisonneuve Rosemont, CIUSSS de l'est de l'Ile de Montréal
Montreal, Quebec, Canada
McGill University, McGill University Health Center, Royal Victoria Hospital
Montreal, Quebec, Canada
Sir Mortimer B. Davis Jewish General Hospital; McGill University
Montreal, Quebec, Canada
The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal
Montreal, Quebec, Canada
Université Laval, Centre de recherche du CHU de Québec
Québec, Quebec, Canada
(CIUSSS de l'Estrie-CHUS); Université de Sherbrooke
Sherbrooke, Quebec, Canada
University of Saskatchewan, Regina General Hospital
Saskatoon, Saskatchewan, Canada