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Muscle Blood Flow Regulation in HFpEF
Sponsor: VA Office of Research and Development
Summary
Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.
Official title: Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans With Heart Failure With Preserved Ejection Fraction: Efficacy of Knee Extensor Training
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2022-07-01
Completion Date
2028-02-29
Last Updated
2026-03-20
Healthy Volunteers
Yes
Conditions
Interventions
Exercise training
Patients with HFpEF will undergo 8 weeks of exercise training.
Locations (1)
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States