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Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture
Sponsor: Mayo Clinic
Summary
The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture.
Official title: Neostigmine and Glycopyrrolate for the Treatment of Post Dural Puncture Headache After Known Dural Puncture With a Tuohy Needle: A Pilot Study
Key Details
Gender
FEMALE
Age Range
18 Years - 54 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2021-11-19
Completion Date
2027-12
Last Updated
2026-03-23
Healthy Volunteers
No
Conditions
Interventions
Neostigmine
IV infusion 20 μg/kg over 10 minutes repeated every 8 hours for a maximum of 3 doses
Glycopyrrolate
IV infusion 4 μg/kg over 10 minutes repeated every 8 hours for a maximum of 3 doses
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States