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Biomarkers for Ventilator-associated Pneumonia
Sponsor: Region Skane
Summary
The purpose of this study is to evaluate different peptide biomarkers, variations in the microbiome and patterns in the bacterial transcriptome as prognostic or diagnostic biomarkers of VAP.
Official title: Biomarkers for Prediction of and Diagnosis of Ventilator-associated Pneumonia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2021-10-15
Completion Date
2028-12-31
Last Updated
2024-11-15
Healthy Volunteers
No
Conditions
Interventions
Heparin-binding protein
Evaluation of the specificity and sensitivity of HBP as diagnostic biomarker for VAP.
Interleukin-26
Evaluation of the specificity and sensitivity of IL-26 as diagnostic biomarker for VAP.
Microbiome
Evaluation of the specificity and sensitivity of the lung microbiome as prognostic biomarker for VAP.
Bacterial transcriptome
Evaluation of the specificity and sensitivity of the bacterial transcriptome as prognostic biomarker for treatment failure of VAP.
Proteome
Evaluation of the specificity and sensitivity of the proteome in mini-BAL as biomarker for VAP.
Locations (5)
Vestre Viken
Drammen, Norway
Hospital de São Francisco Xavier
Lisbon, Portugal
Skåne University Hospital, Dept. of Infectious diseases
Lund, Sweden
Skåne university Hospital, ICU
Malmo, Sweden
Karolinska University Hospital, ICU
Solna, Sweden