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ACTIVE NOT RECRUITING

NCT05117840

Screening for High Frequency Malignant Disease

Sponsor: Guardant Health, Inc.

View on ClinicalTrials.gov

Summary

The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization. The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.

Key Details

Gender

All

Age Range

50 Years - 80 Years

Study Type

OBSERVATIONAL

Enrollment

12000

Start Date

2022-01-13

Completion Date

2026-07-30

Last Updated

2026-04-03

Healthy Volunteers

Yes

Conditions

Lung Cancer

Interventions

DEVICE

Low-dose CT scan

Standard of care screening for individuals at high-risk of lung cancer

Locations (143)

University of Alabama Birmingham Lung Health Center

Birmingham, Alabama, United States

Highlands Oncology Group PA

Fayetteville, Arkansas, United States

Pacific Cancer Medical Center

Anaheim, California, United States

Providence St. Joseph Hospital Eureka Cancer Program

Eureka, California, United States

SoCal Clinical Research

Fountain Valley, California, United States

Advanced Investigative Medicine

Hawthorne, California, United States

Cedars-Sinai Medical Center

Los Angeles, California, United States

California Medical Research Associates Inc.

Northridge, California, United States

Providence Medical Foundation

Santa Rosa, California, United States

Starling Physicians

New Britain, Connecticut, United States

George Washington University Medical Center

Washington D.C., District of Columbia, United States

Central Florida Pulmonary Group, P.A.

Altamonte Springs, Florida, United States

Pulmonary, Critical Care & Sleep Disorders Institute of South Florida

Atlantis, Florida, United States

CTMD Research

Coconut Creek, Florida, United States

Life Arc Research Centers

Coral Gables, Florida, United States

Pulmonary Physicians of South Florida, LLC

Coral Springs, Florida, United States

SIMED Health, LLC

Gainesville, Florida, United States

National Research Institute

Hialeah, Florida, United States

3Sync Research

Hialeah, Florida, United States

Zenith Clinical Research

Hollywood, Florida, United States

Multi-Specialty Research Associates, Inc.

Lake City, Florida, United States

3Sync Research

Lake Worth, Florida, United States

Adtremed INC

Lutz, Florida, United States

Las Mias Research and Medical Center

Miami, Florida, United States

Monzon Clinical Trials

Miami, Florida, United States

Valencia Medical and Research Center

Miami, Florida, United States

Miami Pulmonary Specialists

Miami, Florida, United States

Florida Research Center, Inc.

Miami, Florida, United States

Charisma Medical and Research Center

Miami Lakes, Florida, United States

Adult Medicine of Lake County

Mt. Dora, Florida, United States

Central Florida Pulmonary Group, P.A.

Orlando, Florida, United States

Central Florida Pulmonary Group, P.A.

Orlando, Florida, United States

CTMD Research

Palm Springs, Florida, United States

Coastal Pulmonary and Critical Care, P.L.C.

St. Petersburg, Florida, United States

Adtremed Research Clinic

Tampa, Florida, United States

VICIS Clinical Research

Tampa, Florida, United States

Midtown OB/GYN North

Columbus, Georgia, United States

Pulmonary and Sleep Specialists of Northeast Georgia, PC

Dacula, Georgia, United States

DC Research Works

Marietta, Georgia, United States

Randomize Now, LLC

Peachtree City, Georgia, United States

Pulmonary and Sleep Specialists of Northeast Georgia, PC

Winder, Georgia, United States

Christie Clinic

Champaign, Illinois, United States

Eagle Clinical Research

Chicago, Illinois, United States

Hutchinson Clinic - North Waldron

Hutchinson, Kansas, United States

MedCorps Asthma and Pulmonary Specialists

Maysville, Kentucky, United States

Family Medicine Physicians

Hammond, Louisiana, United States

Willis-Knighton Cancer Center

Shreveport, Louisiana, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

HealthPartners Institute

Minneapolis, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

Memorial Hospital at Gulfport

Gulfport, Mississippi, United States

Olive Branch Family Medical Center

Olive Branch, Mississippi, United States

Family Medical Clinic of North Mississippi

Southaven, Mississippi, United States

Branson Pulmonology and Sleep Medicine

Branson, Missouri, United States

Washington University School of Medicine/Barnes-Jewish Hospital

St Louis, Missouri, United States

Somnos Clinical Research

Lincoln, Nebraska, United States

Great Plains Health

North Platte, Nebraska, United States

Ocean Pulmonary Associates

Brick, New Jersey, United States

Ocean University Medical Center

Brick, New Jersey, United States

RespaCare

Bridgewater, New Jersey, United States

MedCorps Asthma and Pulmonary Specialists

Cape May Court House, New Jersey, United States

Pulmonary & Sleep Disorders of New Jersey

East Brunswick, New Jersey, United States

JFK University Medical Center

Edison, New Jersey, United States

Pulmonary Internists

Edison, New Jersey, United States

Pulmonary Specialists of North Jersey

Englewood, New Jersey, United States

Hackensack University Medical Center

Hackensack, New Jersey, United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States

MedCorps Asthma and Pulmonary Specialists

Linwood, New Jersey, United States

Pulmonary & Sleep Disorders of New Jersey

Monroe, New Jersey, United States

John Theurer Cancer Center at Jersey Shore University Medical Center

Neptune City, New Jersey, United States

Pulmonary Specialists of North Jersey

North Bergen, New Jersey, United States

Respiratory and Sleep Specialists, LLC

Princeton, New Jersey, United States

Riverview Medical Center

Red Bank, New Jersey, United States

North Jersey Pulmonary Associates

Ridgewood, New Jersey, United States

MedCorps Asthma and Pulmonary Specialists

Sewell, New Jersey, United States

Ocean Pulmonary Associates

Toms River, New Jersey, United States

Long Island Pulmonary and Sleep Medicine Associates

Hempstead, New York, United States

Long Island Pulmonary and Sleep Medicine Associates

Rockville Centre, New York, United States

Great Lakes Medical Research

Westfield, New York, United States

CTMD Research, Asheville

Asheville, North Carolina, United States

MacGregor Family Physicians, P.A.

Cary, North Carolina, United States

Durham VA Medical Center

Durham, North Carolina, United States

Clinical Research of Gastonia

Gastonia, North Carolina, United States

Peters Medical Research

High Point, North Carolina, United States

Piedmont Healthcare

Statesville, North Carolina, United States

Wilmington Health

Wilmington, North Carolina, United States

Lillestol Research, LLC

Fargo, North Dakota, United States

Pulmonology Associates Inc.

Broomall, Pennsylvania, United States

Advocare Pulmonary And Sleep Specialists

Exton, Pennsylvania, United States

Advocare Pulmonary And Sleep Specialists

Lansdale, Pennsylvania, United States

Pulmonology Associates Inc.

Paoli, Pennsylvania, United States

Advocare Pulmonary And Sleep Specialists

West Chester, Pennsylvania, United States

Pulmonology Associates Inc.Pulmonology Associates Inc. (Suite 108)

Wynnewood, Pennsylvania, United States

Pulmonology Associates Inc.

Wynnewood, Pennsylvania, United States

Berks Schuylkill Respiratory Specialists, Ltd.

Wyomissing, Pennsylvania, United States

Vista Clinical Research

Columbia, South Carolina, United States

The Jackson Clinic

Jackson, Tennessee, United States

Midsouth Independent Group