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EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
Official title: Endoscopic Ultrasound Guided Liver Biopsy and Portal Pressure Gradient Measurement Compared to the Transjugular Approach: a Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2021-11-04
Completion Date
2025-01-01
Last Updated
2024-12-05
Healthy Volunteers
Yes
Interventions
Transjugular hepatic venous pressure gradient measurement with liver biopsy
This procedure will be performed by an experienced interventional radiologist who will be supported by a radiology technician and nurse. Transjugular hepatic venous pressure gradient measurement will be performed using standard procedure. Following this, a transjugular liver biopsy will be obtained using an 18-gauge transjugular liver biopsy needle.
Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
A linear echoendoscope is inserted with the patient under conscious sedation. Using a through the scope 25-gauge needle connected to a digital manometer, portal and hepatic veins will be punctured under EUS guidance from a trans-gastric/hepatic approach. Following this, EUS-Liver biopsy is then performed immediately following EUS-PPG using a 19-gauge fine needle biopsy (FNB).
Locations (1)
McGill University Health Centre
Montreal, Quebec, Canada