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Pathogen-microbiome Interaction During Helicobacter Pylori Infection
Sponsor: University Hospital Freiburg
Summary
Helicobacter pylori affects the gut microbiome in ways that are only partially understood. In which patients H. pylori causes severe disease and in whom it merely colonizes, possibly even with beneficial effects, is not understood. The investigators are pursuing the hypothesis that changes in the gut microbiome that can be easily measured in stool have such predictive value.
Official title: Pathogen-microbiome Interaction in Human Response and Disease-outcome During Infection and Colonization With Helicobacter Pylori
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
180
Start Date
2022-03-11
Completion Date
2025-12-30
Last Updated
2024-12-05
Healthy Volunteers
Yes
Conditions
Interventions
Analysis of gut microbiome and immune signatures
The investigators will analyse the microbiome composition (16S rDNA-sequencing and metagenomics), microbiome activity (RNA-sequencing of stool bacteria and metabolite sampling) and immune cell activity (leukocyte RNA-sequencing) of all study groups.
Locations (1)
Institute for Microbiology and Hygiene
Freiburg im Breisgau, Baden-Wurttemberg, Germany