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Analysis of Biological Characteristics of Advanced ALK-rearranged NSCLC
Sponsor: Groupe Francais De Pneumo-Cancerologie
Summary
BioEXALK is a prospective study evaluating the biological characteristics of advanced ALK-rearranged NSCLC treated with next generation TKIs in first line, included in the national EXPLORE ALK cohort (GFPC 03-2019), a non-interventional, national, multi-center cohort of ALK-rearranged NSCLC patients. BioExALK study will be proposed to every patient included in the Explore ALK GFPC 03-2019 study. Biological analysis will be performed on tumor tissue at diagnosis and at the time of disease progression when available and on circulating tumor DNA (ctDNA). For plasma testing, after obtained patient consent, blood samples will be taken and analyzed at the Léon Bérard Center (Lyon). Biological analysis on tissue obtained at diagnosis and at disease progression will be collected and be sent for centralized analysis to the Rouen University Hospital.
Official title: Biological Characterization of Advanced ALK-rearranged Non-small Cell Lung (NSCLC) Cancer Included in EXPLOREALK Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-09-22
Completion Date
2027-06-30
Last Updated
2025-08-06
Healthy Volunteers
No
Interventions
RNAseq
1. Tissue : RNAseq will be performed on tumor biopsy (10 slides of 5 microns) to identify the ALK fusion partner and its variant and associated co-mutations. 2. ctDNA : NGS panel on DNA including a large panel of fusions and mutations will be performed on blood samples
Locations (46)
Pneumologie CHU Félix Guyon
Saint-Denis, La Réunion, France
Centre Hospitalier d'Aix en Provence
Aix-en-Provence, France
Pneumologie CHU
Amiens, France
Centre Hospitalier Universitaire
Angers, France
Centre Hospitalier d'Annecy
Annecy, France
Centre Hospitalier du Morvan
Brest, France
Centre François Baclesse
Caen, France
Pneumologie CH Métropole Savoie
Chambéry, France
Oncologie CLCC Jean Perrin
Clermont-Ferrand, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Pneumologie CH Eure-Seine
Évreux, France
Pneumologie CHD Vendée
La Roche-sur-Yon, France
Pneumologie Hôpital Mignot
Le Chesnay, France
Pneumologie CH
Le Mans, France
Oncologie Centre Oscar Lombret
Lille, France
Pneumologie Hôpital Calmette
Lille, France
Pneumologie CHU Limoges
Limoges, France
Hôpital du Scorff
Lorient, France
Pneumologie Hôpital privé Jean Mermoz
Lyon, France
Centre Léon Bérard
Lyon, France
Oncologie Hôpital François Quesnay
Mantes-la-Jolie, France
Pneumologie Hôpital Européen
Marseille, France
Oncologie Institut Paoli Calmette
Marseille, France
Hôpital Nord
Marseille, France
Hôpital de Meaux
Meaux, France
Oncologie Institut du Cancer de Montpellier
Montpellier, France
Oncologie CH Morlaix
Morlaix, France
Pneumologie CHR
Orléans, France
Oncologie Institut Curie
Paris, France
Pneumologie Centre Hospitalier
Pau, France
Hôpital du Haut Leveque
Pessac, France
CHU Pontchailloux
Rennes, France
Hôpital Charles Nicolle
Rouen, France
Pneumologie Hôpital Yves Le Foll
Saint-Brieuc, France
CHU La Réunion Site Sud
Saint-Pierre, France
Institut Lucien Neuwirth
Saint-Priest-en-Jarez, France
Centre Paul Strauss
Strasbourg, France
Pneumologie Hôpital Foch
Suresnes, France
Pneumologie HIA
Talence, France
Pneumologie Hôpital Sainte Musse
Toulon, France
Hôpital d'Instruction des Armées Ste Anne
Toulon, France
Hôpital Larrey
Toulouse, France
Oncologie CH Bretagne-Atlantique
Vannes, France
Centre Hospitalier de Villefranche sur Saone
Villefranche-sur-Saône, France
Oncologie Institut Gustave Roussy
Villejuif, France
Pneumologie CHI
Villeneuve-Saint-Georges, France