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ENROLLING BY INVITATION
NCT05124132
NA

Resilience and Brain Health of Older Adults (MEDEX-2)

Sponsor: Washington University School of Medicine

View on ClinicalTrials.gov

Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Key Details

Gender

All

Age Range

65 Years - Any

Study Type

INTERVENTIONAL

Enrollment

468

Start Date

2019-04-16

Completion Date

2026-08-31

Last Updated

2025-06-18

Healthy Volunteers

No

Interventions

BEHAVIORAL

Mindfulness-Based Stress Reduction

Mindfulness-Based Stress Reduction

BEHAVIORAL

Exercise

Exercise

BEHAVIORAL

Mindfulness-Based Stress Reduction + Exercise

Mindfulness-Based Stress Reduction + Exercise

BEHAVIORAL

Health Education

Health Education

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States