Clinical Research Directory

Inclusion Criteria: * Signature of the form consent for participation in the study * Ph-negative ALL diagnosis without previous treatment. Exclusion Criteria: * ALL with mature B phenotype (sIg +) or with the cytogenetic alterations characteristic of ALL mature B (t (8,14), t (2, 8), t (8, 22)). * Ph-positive ALL * Acute leukemias of ambiguous lineage (undifferentiated or mixed phenotype). * Patients with a history of coronary, valvular or hypertensive heart disease, that contraindicate the use of anthracyclines. * Patients with chronic liver disease in the activity phase and / or Bilirubin\> 2 mg / dl and / or transaminases 5 times the normal limit, not related to ALL. * Patients with severe chronic respiratory failure. * Renal failure and / or creatininemia\> 2 mg / dl not related to ALL. * Serious neurological disorders, not related to leukemic disease. * General condition affected (grades 3 and 4), not attributable to ALL. * Uncontrolled infection by HIV, HTLV-1, HBV, HCV. * Patient not a candidate for treatment based on the criteria of the treating physician. * Pregnant women will have to be evaluated by a multidisciplinary team and an ethics committee.