Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Safety and Efficacy of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥60 Years of Age
Sponsor: ModernaTX, Inc.
Summary
The main purpose of Part A of this study is to evaluate the safety and tolerability of mRNA-1345 vaccine and to demonstrate the efficacy of a single dose of mRNA-1345 vaccine in the prevention of a first episode of RSV-associated lower respiratory tract disease (RSV-LRTD) as compared with placebo from 14 days postinjection through 12 months. The main purpose of Part B of this study is to evaluate the safety, tolerability and immunogenicity of a booster dose (BD) of mRNA-1345 administered 24 months after the primary dose.
Official title: A Phase 2/3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of mRNA-1345, an mRNA Vaccine Targeting Respiratory Syncytial Virus (RSV), in Adults ≥60 Years of Age
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
36814
Start Date
2021-11-17
Completion Date
2025-07-28
Last Updated
2026-09-29
Healthy Volunteers
Yes
Conditions
Interventions
Placebo
0.9% sodium chloride (normal saline) injection
mRNA-1345
Sterile liquid for injection
Locations (269)
AES - DRS - Synexus Clinical Research US, Inc. - Birmingham
Birmingham, Alabama, United States
Accel Research Site - Achieve - Birmingham
Birmingham, Alabama, United States
Lakeview Clinical Research
Guntersville, Alabama, United States
AES - DRS - Optimal Research Alabama - Huntsville
Huntsville, Alabama, United States
Hope Research Institute LLC - Hunt - PPDS
Hunt, Arizona, United States
Hope Research Institute LLC - Hunt - PPDS
Hunt, Arizona, United States
Desert Clinical Research, LLC - CCT
Mesa, Arizona, United States
Hope Research Institute LLC - Phoenix - Hunt - PPDS
Phoenix, Arizona, United States
AES - DRS - Synexus Clinical Research US, Inc. - Phoenix Central
Phoenix, Arizona, United States
Synexus Clinical Research US, Inc. - Phoenix Southeast
Phoenix, Arizona, United States
Tucson Neuroscience Research - M3 WR
Tucson, Arizona, United States
Baptist Health Center for Clinical Research
Little Rock, Arkansas, United States
Velocity Clinical Research, Banning
Banning, California, United States
Hope Clinical Research, LLC
Canoga Park, California, United States
Velocity Clinical Research - Chula Vista - PPDS
Chula Vista, California, United States
PPD Virtual - Science 37, Inc
Culver City, California, United States
Velocity Clinical Research, San Diego
La Mesa, California, United States
PRI, LLC - Los Alamitos - M3 WR
Los Alamitos, California, United States
PRI, LLC - Newport Beach - M3 WR
Newport Beach, California, United States
FOMAT Medical Research - FOMAT - HyperCore - PPDS
Oxnard, California, United States
Reddy Care Medical
Pomona, California, United States
Paradigm Clinical Research Institute Inc - ClinEdge - PPDS
Redding, California, United States
Medical Center For Clinical Research - M3 WR
San Diego, California, United States
Lynn Institute of Denver
Aurora, Colorado, United States
Tekton Research - Fort Collins - PPDS
Fort Collins, Colorado, United States
Tekton Research - Longmont - PPDS
Longmont, Colorado, United States
Paradigm Clinical Research Institute Inc - ClinEdge - PPDS
Wheat Ridge, Colorado, United States
Clinical Research Consultants LLC - ClinEdge - PPDS
Milford, Connecticut, United States
Washington Health Institute
Washington D.C., District of Columbia, United States
Velocity Clinical Research, New Smyrna Beach
Edgewater, Florida, United States
Fleming Island Clinical Research Center
Fleming Island, Florida, United States
Velocity Clinical Research - Hallandale Beach - PPDS
Hallandale, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Multi-Specialty Research Associates, Inc. M3 WR
Lake City, Florida, United States
Accel Research Sites - Maitland - ERN - PPDS
Maitland, Florida, United States
Spotlight Research Center, LLC
Miami, Florida, United States
IMA Clinical Research - Manhattan - PPDS
Miami Beach, Florida, United States
AES - DRS - Synexus Clinical Research US, Inc. - The Villages
Orlando, Florida, United States
Health Awareness Inc
Port Saint Lucie, Florida, United States
IMA Clinical Research - Saint Petersburg - PPDS
St. Petersburg, Florida, United States
AES - DRS - Synexus Clinical Research US, Inc. - St. Petersburg
St. Petersburg, Florida, United States
Clinical Trials of Tampa
Tampa, Florida, United States
Palm Beach Research - ClinEdge - PPDS
West Palm Beach, Florida, United States
Clinical Site Partners - Winter Park - HyperCore -PPDS
Winter Park, Florida, United States
Mount Vernon Clinical Research, LLC - M3 WR
Atlanta, Georgia, United States
Masters of Clinical Research Inc
Augusta, Georgia, United States
Centricity Research - Roswell - HyperCore - PPDS
Columbus, Georgia, United States
iResearch Atlanta
Decatur, Georgia, United States
Javara, Inc./Privia Medical Group Georgia, LLC
Fayetteville, Georgia, United States
Drug Studies America - ClinEdge - PPDS
Marietta, Georgia, United States
Randomize Now -Commerce Dr
Peachtree City, Georgia, United States
Velocity Clinical Research (Savannah - Georgia) - PPDS
Savannah, Georgia, United States
Clinical Research Atlanta - ERN-PPDS
Stockbridge, Georgia, United States
East West Medical Research Institute
Honolulu, Hawaii, United States
Velocity Clinical Research - Boise - PPDS
Meridian, Idaho, United States
AES - DRS - Synexus Clinical Research US, Inc. - Chicago
Chicago, Illinois, United States
Affinity Health (Oak Brook)
Oak Brook, Illinois, United States
DM Clinical - Chicago
River Forest, Illinois, United States
AES - DRS - Synexus Clinical Research US, Inc. - Evansville
Evansville, Indiana, United States
Velocity Clinical Research - Valparaiso - PPDS
Valparaiso, Indiana, United States
Johnson County Clin-Trials
Lenexa, Kansas, United States
Versailles Family Medicine - CCT - PPDS
Versailles, Kentucky, United States
Velocity Clinical Research (Baton Rouge - Louisiana) - PPDS
Baton Rouge, Louisiana, United States
Benchmark Research - Covington - HyperCore - PPDS
Covington, Louisiana, United States
Benchmark Research - Metairie - HyperCore - PPDS
Metairie, Louisiana, United States
IMA Clinical Research - Monroe, LA - PPDS
Monroe, Louisiana, United States
DelRicht Clinical Research, LLC - Internal - Covington - PPDS
New Orleans, Louisiana, United States
Privia Medical Group, LLC - Annapolis - Javara - PPDS
Annapolis, Maryland, United States
CBH Health - CenExel CBH - PPDS
Gaithersburg, Maryland, United States
Velocity Clinical Research (Rockville - Maryland) - PPDS
Rockville, Maryland, United States
Great Lakes Research Institute
Southfield, Michigan, United States
DM Clinical Research - Southfield - ERN - PPDS
Southfield, Michigan, United States
Clinical Research Institute, Inc - CRN - PPDS
Minneapolis, Minnesota, United States
AES - DRS - Synexus Clinical Research US, Inc. - Minneapolis
Richfield, Minnesota, United States
AES - DRS - Synexus Clinical Research US, Inc. - St. Louis
Creve Coeur, Missouri, United States
Montana Medical Research
Missoula, Montana, United States
Boeson Research MSO - Missoula - ERN - PPDS
Missoula, Montana, United States
Skyline Medical Center, PC - CCT Research
Elkhorn, Nebraska, United States
Methodist Physicians Clinic - CCT Research - PPDS
Fremont, Nebraska, United States
Velocity Clinical Research (Grand Island - Nebraska) - PPDS
Grand Island, Nebraska, United States
Velocity Clinical Research (Lincoln - Nebraska) - PPDS
Lincoln, Nebraska, United States
Velocity Clinical Research (Omaha - Nebraska) - PPDS
Omaha, Nebraska, United States
CCT Research
Papillion, Nebraska, United States
HEALOR Primary Care - Physicians Las Vegas - CCT
Las Vegas, Nevada, United States
Excel Clinical Research - Las Vegas
Las Vegas, Nevada, United States
IMA Clinical Research - Raritan - PPDS
Raritan, New Jersey, United States
Riverside Medical Group - Circuit - PPDS
Secaucus, New Jersey, United States
Velocity Clinical Research - East Syracuse - PPDS
East Syracuse, New York, United States
Velocity Clinical Research (Endwell - New York) - PPDS
Endwell, New York, United States
Drug Trials America
Hartsdale, New York, United States
AES - DRS - Synexus Clinical Research US, Inc. - New York
New York, New York, United States
Rochester Clinical Research, Inc
Rochester, New York, United States
Carolina Institute for Clinical Research - M3 WR
Fayetteville, North Carolina, United States
Triad Clinical Trials
Greensboro, North Carolina, United States
Trial Management Associates, LLC
Wilmington, North Carolina, United States
CTI Clinical Research
Cincinnati, Ohio, United States
Velocity Clinical Research (Cincinnati - Ohio) - PPDS
Cincinnati, Ohio, United States
Velocity Clinical Research - Cincinnati - PPDS
Cincinnati, Ohio, United States
AES - DRS - Synexus Clinical Research US, Inc. - Cincinnati
Cincinnati, Ohio, United States
Tekton Research - Oklahoma - PPDS
Edmond, Oklahoma, United States