Inclusion Criteria:
* Men and women between the ages of 18 and 65 at the time of dupilumab initiation.
* Subjects must have either one keloid with ≥ 2 cm length-wise or at least two keloids with ≥ 0.4 cm (width) x 0.4 cm (length)
* Subjects must be able to understand and communicate with the investigator and comply with the requirements of the study and must give a written, signed and dated informed consent before any study related activity is performed.
Exclusion Criteria:
* History of an ongoing, chronic or recurrent infectious disease, or evidence of tuberculosis (Tb) infection as defined by a positive QuantiFERON TB-Gold test at screening.
* Known infection with HIV, hepatitis B or hepatitis C at screening.
* Are currently pregnant, breastfeeding, or planning to get pregnant during the study.
* Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unwilling to use effective contraception during the study and for 8 weeks after stopping treatment. Methods of acceptable birth control are listed below under "Women of Childbearing Potential"
* Previous hypersensitivity reaction to dupilumab.
* Patients with acute asthma, acute bronchospasm or status asthmaticus.
* Patients with known helminth infections.
* Currently on any other immunosuppressant systemic medication or within 28 days of baseline visit.
* Underlying condition (including, but not limited to metabolic, hematologic, renal, hepatic, pulmonary, neurologic, endocrine, cardiac, infectious or gastrointestinal) which in the opinion of the investigator significantly immunocompromises the subject and/or places the subject at unacceptable risk for receiving an immunomodulatory therapy.
* Are participating in another study using an investigational agent or procedure during participation in this study or within 28 days prior to baseline visit.
* Any other treatment for keloids with 28 days prior to baseline visit, including silicone gel/sheets, laser therapy, intralesional steroid or 5-fluorouracil injections, topical steroid, cryotherapy, surgery, or radiation therapy.
* Has had a live vaccine
