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Monitoring for Cancer Spread to the Central Nervous System (CNS) in People With Breast Cancer
Sponsor: Memorial Sloan Kettering Cancer Center
Summary
The researchers doing this study think that performing scans of the brain and testing cerebrospinal fluid (CSF) in people with HER2-positive breast cancer may be an effective way of identifying the early onset of CNS metastases (such as brain cancer). If the researchers can identify the early onset of CNS metastases, they can immediately treat that cancer and possibly prevent it from worsening. Currently, people with breast cancer don't usually have scans of the brain or CSF testing unless they are experiencing symptoms of CNS metastases.
Official title: Feasibility of Multi-modality Central Nervous System Evaluation in HER2+ Breast Cancer Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
9
Start Date
2022-07-13
Completion Date
2026-07
Last Updated
2026-01-30
Healthy Volunteers
No
Conditions
Interventions
MRI
MRI Brain (unless already done as standard of care within 2 months on enrollment to evaluate for CNS disease) MRI Brain at 2 timepoints 6 months apart (+/- 8 weeks).
Lumbar puncture
LP at 2 timepoints 6 months apart (+/- 8 weeks). LP will be performed to analyze cerebrospinal fluid for: cytology, circulating tumor cells and cell-free DNA.
Locations (1)
Memorial Sloan Kettering Cancer Center
New York, New York, United States