Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
ACTIVE NOT RECRUITING
NCT05131659
NA

Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

Sponsor: Children's National Research Institute

View on ClinicalTrials.gov

Summary

This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation using model-based functional magnetic resonance imaging (m-fMRI). The study proposes that variability in learning mechanisms is associated with behavioral flexibility and explains differences in adaptive and treatment outcomes. The study employs a longitudinal case-controlled design in 60 14-18 year old youth with ASD at 3 time-points 8 months apart, each including m-fMRI during learning and behavioral measurement of executive and adaptive function. Aim 1 tests the hypothesis that individual variation in learning biases and their neural correlates predicts behavioral flexibility and is stable over time. Aim 2 tests plasticity of learning mechanisms induced by a cognitive-behavioral intervention for flexibility. Aim 3 tests hypothesis about intervention-induced plasticity of neural functional connectivity.

Key Details

Gender

All

Age Range

14 Years - 18 Years

Study Type

INTERVENTIONAL

Enrollment

64

Start Date

2021-10-20

Completion Date

2026-05-31

Last Updated

2026-02-12

Healthy Volunteers

No

Interventions

BEHAVIORAL

Executive function group therapy

This executive function group therapy curriculum for adolescents uses cognitive behavioral therapy techniques, and focuses on key functions needed for adult success, such as: self-advocacy, flexibility, time management, motivation, goal setting, developing plans, monitoring progress. Guided practice begins with concrete interventionist support and moves to interventionist cueing, self-cueing, and finally automatic use of the skills without support.

Locations (2)

Children's National Hospital

Washington D.C., District of Columbia, United States

Georgetown University

Washington D.C., District of Columbia, United States