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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Sponsor: Florida International University
Summary
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2022-08-30
Completion Date
2027-12-31
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD)
CBT-AD is a behavioral intervention administered either in person or via Zoom. Each session lasts approximately 50 minutes. Participants will receive up to 12 individually delivered sessions over 4 months. Participants receive up to three individually delivered booster sessions through 6 months.
Antiretroviral Therapy (ART) Adherence Counseling
This treatment involves a single session integrating CBT for depression with CBT for adherence following our "Life-Steps" approach.
Locations (2)
University of Miami Neuroimaging Facility
Coral Gables, Florida, United States
Care Resource - Midtown Miami
Miami, Florida, United States