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A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia
Sponsor: Gangnam Severance Hospital
Summary
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.
Official title: A Single-blinded Randomized-controlled Study to Reduce Persistent Post-mastectomy Pain Using Multimodal Opioid-free Anesthesia
Key Details
Gender
FEMALE
Age Range
19 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
230
Start Date
2021-12-16
Completion Date
2027-10-31
Last Updated
2025-11-21
Healthy Volunteers
No
Interventions
Opioid-free anesthesia
OFA group will be sedated using dexmedetomidine and lidocaine.
Conventional opioid-based anesthesia
Conventional opioid-based anesthesia group will be sedated using remi-fentanyl
Locations (1)
Gangnam Severance Hospital
Seoul, South Korea