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Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
Sponsor: University of Texas Southwestern Medical Center
Summary
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2022-09-14
Completion Date
2028-03-30
Last Updated
2026-02-17
Healthy Volunteers
Yes
Interventions
Sodium Phosphate
Sodium Phosphate 2 capsules daily (containing a total of 500 mg of Pi, 372mg of sodium)
Sodium Chloride
Sodium Chloride 2 capsules daily (NaCl, containing a total of 372mg of sodium)
Locations (1)
University of Texas Southwestern
Dallas, Texas, United States