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rTMS-augmented Written Exposure Therapy for PTSD
Sponsor: VA Office of Research and Development
Summary
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.
Official title: Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans With PTSD
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
98
Start Date
2022-01-03
Completion Date
2027-01-29
Last Updated
2026-01-12
Healthy Volunteers
No
Conditions
Interventions
Written Exposure Therapy
Narrative written disclosure of trauma administered in an evidence-based protocol.
repetitive transcranial magnetic stimulation
Noninvasive magnetic neuromodulation device
Locations (1)
Central Texas Veterans Health Care System, Temple, TX
Temple, Texas, United States