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RECRUITING
NCT05149534
NA

rTMS-augmented Written Exposure Therapy for PTSD

Sponsor: VA Office of Research and Development

View on ClinicalTrials.gov

Summary

Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.

Official title: Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans With PTSD

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

98

Start Date

2022-01-03

Completion Date

2027-01-29

Last Updated

2026-01-12

Healthy Volunteers

No

Interventions

BEHAVIORAL

Written Exposure Therapy

Narrative written disclosure of trauma administered in an evidence-based protocol.

DEVICE

repetitive transcranial magnetic stimulation

Noninvasive magnetic neuromodulation device

Locations (1)

Central Texas Veterans Health Care System, Temple, TX

Temple, Texas, United States