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Diagnostic Value of sFlt-1/PlGF Ratio for the Etiology of Intra Uterine Growth Restriction - ANGIOPAG
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The main aim of this project is to determine the Placental Growth Factor and Vascular Endothelial Growth Factor ratio's performance (sFlt-1/PlGF) for the etiological diagnosis of vascular Intrauterine growth restriction (IUGR) compared to a non-vascular IUGR.
Official title: Diagnostic Value of sFlt-1/PlGF Ratio for the Etiology of Intra Uterine Growth Restriction
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
167
Start Date
2020-01-08
Completion Date
2024-01-29
Last Updated
2026-08-12
Healthy Volunteers
No
Interventions
Blood test at time of inclusion for sFlt-1/PlGF ratio
As part of the research, a blood sample is taken to measure the sFLT-1 and PlGF ratio at the inclusion visit.
Follow-up blood test 2 to 4 weeks after inclusion
As part of the research, a blood sample is taken to measure the sFLT-1 and PlGF ratio at the follow-up visit (about 2-4 weeks after inclusion). This second sample is not mandatory for the evaluation of the study's main endpoint.
Placenta analysis for all included patients, even in case of normal birthweight
After delivery, the placenta of each included patient is sent to anatomo-pathology (even in case of normal weight of the baby at birth). An anatomopathologist referent, designated for the study in each center, performs an analysis (aware of the clinic but not of the sFLT-1/PlGF ratio results), according to the benchmark criteria grid. Local analysis will classify the placenta as "vascular IUGR" or "nonvascular IUGR".
Locations (1)
Hôpital Louis Mourier
Colombes, France