Clinical Research Directory

Inclusion Criteria: * The age of the patient is ≥ 18. * The patient has undergone an urgent or emergent primary cardiac valvar operation as treatment for IVDA endocarditis, with blood cultures positive for Streptococcus, Enterococcus faecalis, Staphylococcus aureus, or coagulase-negative Staphylococci * The patient has received 2 weeks of postoperative inpatient IV antibiotic therapy with negative blood cultures and no residual active infection by imaging (i.e. computerized axial tomography, echocardiography) * The patient has the capacity to participate in a compliance tracking tool for medication administration (e.g. a centrally managed core site mobile Medisafe compliance https://www.medisafe.com/) as confirmed by both a physician and a care management team member Exclusion Criteria: * Inability to give informed consent * Residual infection requiring IV antibiotic therapy * Any persistent secondary noncardiac infection (e.g. infections of solid organs or joints) * Known poor compliance or deemed incapable to comply with the compliance tracking tool * Reduced absorption or inability to receive oral treatment due to a gastrointestinal disorder * Any infection involving a more virulent organisms, such as fungal infections or infections with Serratia or HACEK infections (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, Kingella). * Cancer not otherwise in remission or in need of current or future oncologic therapy * Medically immunocompromised state * Reoperative valvar operation for IVDA endocarditis * History of habitual noncompliance * Pregnancy * Mental incapacity * Unable to perform local or institutional medical and psychiatric follow up * Unstable home environment * Inadequate access to mobile cell service (geographic/rurality)