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Optimal Treatment Protocol for Selective Laser Trabeculoplasty - Repeat Trial
Sponsor: Vastra Gotaland Region
Summary
Glaucoma is a common eye disease that can lead to blindness. The only known way to reduce the rate of disease progression is by reducing the pressure in the eye (the intraocular pressure, IOP). Selective laser trabeculoplasty (SLT) is an ophthalmic laser intervention with the purpose of reducing the IOP. SLT can be performed in different ways, with four of the treatment protocols being evaluated in the Optimal SLT (OSLT) trial. SLT is a repeatable procedure, but scientific evidence is scarce regarding more than one repetition. In this trial, patients included in the OSLT trial will be invited to the extended trial (OSLT-R), for further follow-up and re-treatment with SLT, if needed.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2022-01-10
Completion Date
2027-12-31
Last Updated
2025-09-30
Healthy Volunteers
No
Interventions
SLT
A drop of Pilocarpine 4% is administered to the eye 20 minutes before SLT. Immediately before SLT a drop of Tetracaine hydrochloride 1% is administered. Selective laser trabeculoplasty is conducted through a Latina lens, in a fashion determined by randomization to a study arm (see description).
Locations (2)
Department of Ophthalmology, Skaraborg Hospital
Skövde, Västra Götaland County, Sweden
Department of Ophthalmology, NU Hospital Group
Uddevalla, Västra Götaland County, Sweden