Clinical Research Directory

Inclusion Criteria: 1. Subjects aged between 18 and 55 years (from both sexes \[or genders\]); 2. Diagnosed with CUD (moderate or severe) according to the Structured Clinical Interview for DSM-IV (SCID) (mode of cannabis consumption can be inhalation or ingestion); 3. Diagnosis of current (past 30 days) PTSD, using the CAPS-5 on screening; 4. On antidepressant medication(s) for at least 1 month (to ensure safety and homogeneity as PTSD treatment of our population); 5. Be able to provide written informed consent; and 6. Be able to communicate in English. Exclusion Criteria: 1. diagnosed with a severe or unstable medical illness that precludes safe participation in the study as per the study physician; 2. diagnosed with schizophrenia, schizoaffective disorder, or bipolar disorder or current acute psychosis or mania based on DSM-5 criteria; 3. current suicidality risk as indicated by the Columbia Suicide Severity Rating Scale (C-SSRS) with concurrence after the study physician's evaluation if the response to C-SSRS questions 1 or 2 is "yes" 34; and 4. have pain interfering with normal function as reported by the 12-Item Short Form Survey (SF-12) (moderate or higher interference).