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COMPLETED

NCT05162846

Michigan Genetic Hereditary Testing (MiGHT)

Sponsor: University of Michigan Rogel Cancer Center

View on ClinicalTrials.gov

Summary

The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase the likelihood of a participant obtaining guideline-concordant genetic testing. Eligible participants will be randomized (assigned) to one of the following interventions: 1) Virtual genetics navigator, a mobile-optimized website, designed by the investigators, that delivers tailored messages and content; 2) two motivational interviewing (MI) telephone calls delivered by trained genetics health coaches; or 3) usual care.

Official title: Methods for Increasing Genetic Testing Uptake in Michigan

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

793

Start Date

2022-04-21

Completion Date

2025-11-21

Last Updated

2026-08-18

Healthy Volunteers

Yes

Conditions

Breast Cancer Colorectal Cancer Ovarian Cancer Prostate Cancer Pancreatic Cancer Endometrial Cancer History of Cancer

Interventions

OTHER

Publicly available genetic testing resources

Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.

BEHAVIORAL

Virtual genetics navigator

A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).

BEHAVIORAL

Motivational interviewing (MI)

At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.

Inclusion Criteria: * Able to speak and read English * Access to the internet * Completed the Family Health History Tool (FHHT) * Meeting clinical criteria for genetic evaluation due to any of the below: 1. Personal history of Breast cancer either: * i. Diagnosed under 50 * ii. Personal or family history of triple negative breast cancer * iii. Ashkenazi Jewish ancestry * iv. Male proband * v. 1st or 2nd degree relative with ovarian cancer, pancreatic cancer, breast cancer diagnosed under 50, or male breast cancer 2. Personal history of prostate cancer either: * i. Diagnosed under 50 * ii. Ashkenazi Jewish ancestry * iii. 1st or 2nd degree relative with ovarian cancer, pancreatic cancer, breast cancer diagnosed under 50, or male breast cancer 3. Personal history of any cancer or no personal history of cancer with either: * i. PREMM score ≥ 2.5% * ii. 1st degree relative with pancreatic, or male breast cancer * iii. 1st or 2nd degree relative with ovarian cancer * iv. 1st degree relative with any of these cancers diagnosed under 50: colon, endometrial, or breast * v. Ashkenazi Jewish ancestry and 1st or 2nd degree relative with breast cancer 4. Personal history of endometrial cancer diagnosed under 50 5. Personal history of colorectal cancer diagnosed under 50 6. Personal history of renal cancer diagnosed under 46 7. Personal history of sarcoma diagnosed under 46 and a 1st or 2nd degree relative with sarcoma, breast cancer, or brain cancer diagnosed under 56 8. Personal history of brain cancer diagnosed under 46 and a 1st or 2nd degree relative with sarcoma, breast cancer, or brain cancer diagnosed under 56 9. Personal history of any two of the following cancers with at least one of them diagnosed under 46: breast, sarcoma, or brain 10. Personal history of ovarian cancer 11. Personal history of pancreatic cancer 12. Personal history of adrenal cortical carcinoma Exclusion Criteria: * Prior clinical germline genetic testing for cancer or already have an upcoming appointment scheduled with a genetics provider

Locations (1)

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, United States