Clinical Research Directory

Inclusion Criteria: * Male or female ≥ 2 and \< 80 years of age. * Refractory to medical management of symptoms for at least 1 year. * Documentation of OTCS, as defined by a total score of at least 30 on the following scale: OCCULT Grading Scale (Score 0-100) Orthopedic Abnormality: 0-15; Central Nervous System Dysfunction: 0-25; Cutaneous Stigmata: 0-10; Urological or Bowel Dysfunction: 0-25; Lumbosacral Anatomy: 0-15; Tissue Integrity Disorder: 0-10. Exclusion Criteria: * Subjects \< 2 or \> 80 years of age. * Radiographically identified tethered cord, as defined by any of the following: * A low-lying conus (at or below the L2-3 disc space) * A thickened filum (\>2 mm) * Fat in the filum or lipoma * Distinct adhesion or tethering. * A history of Meningocele manqué or Myelomeningocele. * Cutaneous markings of dermal sinus tract. * History of prior surgery on the lumbar spine. * History of prior surgery for spinal dysraphism. * History of prior infection or autoimmune condition of the central nervous system.