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DBS Recordings to Characterize Movement Facilitation in Parkinson's Disease
Sponsor: University of California, Los Angeles
Summary
Several strategies or contexts help patients with Parkinson's disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies use intraoperative recordings during DBS surgery for Parkinson's disease to understand the brain mechanisms supporting improved movements elicited by external cues. The central hypothesis is that distinct networks are involved in movement improvement depending on characteristics of the facilitating stimulus. Participants will perform movement tasks during awake surgery performed exclusively for clinical indications. The identified biomarkers may provide targets for future neuromodulation therapies to improve symptoms that are refractory to current treatments, such as freezing of gait.
Official title: Intra-operative Recordings to Characterize Movement Facilitation in Parkinson's Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2022-03-03
Completion Date
2026-09
Last Updated
2025-11-28
Healthy Volunteers
Yes
Conditions
Interventions
Movement task
Computer task with experimental conditions manipulating sensory and motivation cues for movement.
Locations (1)
University of California Los Angeles
Los Angeles, California, United States