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Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)
Sponsor: University of Oklahoma
Summary
This proposal aims to determine the effects of tVNS on autonomic tone, atrial substrate and neuromodulators in patients with paroxysmal atrial fibrillation (AF), investigate the chronic effects of optimal tVNS on AF burden in patients with paroxysmal AF over a 6-month period, compared with sham stimulation, and identify physiological and biochemical markers of response to chronic tVNS.
Key Details
Gender
All
Age Range
21 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2022-09-14
Completion Date
2026-05-29
Last Updated
2024-03-06
Healthy Volunteers
No
Conditions
Interventions
Transcutaneous Electrical Nerve Stimulation Device
Low-level, electrical stimulation of the outer ear (LLTS), using a transcutaneous electrical nerve stimulation (TENS) device.
Locations (1)
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States