Clinical Research Directory

Inclusion criteria: * Patients ages 12 months-18 years * Presence of clinical symptoms related to esophageal dysfunction such as: feeding aversion, failure to thrive, vomiting, abdominal pain, dysphagia, heartburn, and food impaction * Histologic criteria for the diagnosis of EoE with ≥15 eosinophils per high power field from review of a total of six biopsies obtained from the distal and mid (three from each site) esophagus in subjects who were adequately pre-treated with a proton-pump inhibitor- 1mg/kg/dose twice daily, up to a maximum of 40mg or 30mg per dose depending on preparation for 6-8 weeks or had a normal 24 hour ph probe study18 * Patients who agree to 4-FED as their treatment of EoE Exclusion criteria: * Those patients who are on oral or swallowed steroids (prior use of steroids that was discontinued more than two months prior to enrollment does not constitute an exclusion criterion) * Patients who are unable to tolerate the 4-FED * Patients with concurrent eosinophilic gastroenteritis or eosinophilic colitis