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Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Sponsor: University Hospital, Basel, Switzerland
Summary
This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.
Official title: INsIDER: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2018-09-04
Completion Date
2028-12
Last Updated
2024-12-16
Healthy Volunteers
Yes
Conditions
Interventions
MRI
Each enrolled subject will undergo a MRI at baseline and a second MRI at 2 years (+/- 3 months) follow-up.
Neurocognitive examination for healthy subjects
Neurocognitive examination for healthy subjects will be performed at both baseline and follow-up
blood sampling
Each enrolled subject will undergo a blood sampling (10 ml) at baseline
Locations (1)
University Hospital Basel, Department of Neurology
Basel, Switzerland