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COMPLETED
NCT05184361
NA

Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity

Sponsor: Universidade do Porto

View on ClinicalTrials.gov

Summary

One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain. Therefore, the aim of this study is to evaluate the effects of an intermittent versus a continuous energy restriction in body composition (body weight, fat mass and fat-free mass) and metabolic adaptation, in women with obesity.

Key Details

Gender

FEMALE

Age Range

20 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

75

Start Date

2022-01-13

Completion Date

2024-06-30

Last Updated

2026-07-22

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Intermittent energy restriction (IER)

Both groups will be accompanied by a registered dietitian in order to provide an individual and personalized diet plan that will suppress the respective daily requirements for each phase. Macronutrient distribution will be the following: 35% protein, 35% carbohydrate and 30% fat. Daily energy requirements (DER) will be calculated by multiplying measured RMR (through indirect calorimetry) by physical activity level (PAL), assessed by accelerometry. In order to achieve a neutral EB, 100% of their daily energy requirements (DER) will be prescribed for each participant. For both groups, an energy restriction of 33% of one's DER will be created. The IER group will alternate between 2-weeks in energy restriction (67% DER) and 1-week in neutral EB (100% DER), in a total of 23-weeks. The IER group will alternate between 2-weeks in energy restriction (67% DER) and 1-week in neutral EB (100% DER), in a total of 23-weeks.

BEHAVIORAL

Continuous energy restriction (CER)

A dietary plan comprising 67% of DER will be prescribed to the CER group. Participants will be asked to follow this plan in a total of 16-weeks, without interruptions.

Locations (1)

Faculdade de Motricidade Humana da Universidade de Lisboa

Cruz Quebrada, Lisbon District, Portugal