Clinical Research Directory

Inclusion Criteria: 1. Exposed: * Heart transplant recipients * "De novo" antiHLA detection (after heart transplant): * Mean fluorescence intensity (MFI)) \> 2000 for donor-specific antibodies * Standard fluorescence intensity (SFI) \> 150 000 for non-donor specific antibodies * Detailed immunological history: * Determination of anti-HLA antibodies before heart transplant. * Serial determination of anti-HLA antibodies during heart transplantation follow-up * Known HLA typing of the donor. 2. Non-exposed: Heart transplant procedure contemporary to the index case with negative anti-HLA antibodies. Exclusion Criteria: * Recipient of a second HT * Multiple organ transplantation * Unknown immunological history * Recipients sensitized with anti-HLA antibodies against donor's HLA before the transplant * CMR contrast will not be administered in patients with glomerular filtration rate \< 30 ml/kg/1.73m2 * Patients with implanted cardiac devices or any other magnetic resonance non-compatible metallic prosthetic material will not undergo CMR.