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Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis
Sponsor: Guangdong Provincial People's Hospital
Summary
Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis. Hyperbaric oxygen can improve the tissue after radiation by promoting the function of vascular endothelial cells and fibroblasts, and reducing the secretion of inflammatory factors, thereby inhibiting the process of fibrosis and fiber atrophy after radiotherapy, and promoting tissue repair. Therefore, it has the potential value of treating chronic radiation injury. We aim to investigate whether hyperbaric oxygen treatment can reduce the incidence of radiation pneumonia and improve patients' quality of life, and to evaluate its safety and the impact on the patients' long-term survival outcomes.
Official title: Study on the Effectiveness and Safety of Hyperbaric Oxygen Therapy for Preventing Radiation Pneumonitis Caused by Radiotherapy and Chemotherapy of Breast Cancer
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
380
Start Date
2022-03-01
Completion Date
2026-12-31
Last Updated
2025-02-12
Healthy Volunteers
No
Conditions
Interventions
hyperbaric oxygen therapy
hyperbaric oxygen therapy
Locations (1)
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China