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RECRUITING
NCT05189496
NA

Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis

Sponsor: Guangdong Provincial People's Hospital

View on ClinicalTrials.gov

Summary

Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis. Hyperbaric oxygen can improve the tissue after radiation by promoting the function of vascular endothelial cells and fibroblasts, and reducing the secretion of inflammatory factors, thereby inhibiting the process of fibrosis and fiber atrophy after radiotherapy, and promoting tissue repair. Therefore, it has the potential value of treating chronic radiation injury. We aim to investigate whether hyperbaric oxygen treatment can reduce the incidence of radiation pneumonia and improve patients' quality of life, and to evaluate its safety and the impact on the patients' long-term survival outcomes.

Official title: Study on the Effectiveness and Safety of Hyperbaric Oxygen Therapy for Preventing Radiation Pneumonitis Caused by Radiotherapy and Chemotherapy of Breast Cancer

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

380

Start Date

2022-03-01

Completion Date

2026-12-31

Last Updated

2025-02-12

Healthy Volunteers

No

Interventions

BEHAVIORAL

hyperbaric oxygen therapy

hyperbaric oxygen therapy

Locations (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China