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Immune Modulation by Exosomes in COVID-19
Sponsor: University of Ulm
Summary
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
Official title: Immune Modulation by Stem Cell Derived Exosomes in Critically Ill COVID-19
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2021-12-22
Completion Date
2026-12-31
Last Updated
2024-01-17
Healthy Volunteers
Yes
Interventions
Application of exosomes in a whole blood assay
Co-incubation of patient-derived whole blood samples with mesenchymal stem cell derived exosomes and read-out of biomarkers, RNA and immune phenotypes after 24h.
Locations (1)
Ulm University Hospital, Clinic of Anesthesiology and Intensive Care Medicine
Ulm, Germany