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Respiratory Dysbiosis in Preschool Children with Asthma: Predictive of a Severe Form
Sponsor: University Hospital, Brest
Summary
The prevalence of asthma in preschool children is between 11 and12%. Inhaled corticosteroid therapy is the main therapy used, however this treatment seems insufficiently effective in some children. Recent research in cystic fibrosis has made it possible to highlight pulmotypes corresponding to the different stages of pulmonary dysbiosis, and a predictive microbiological signature of an increased risk of early primocolonization to P. aeruginosa. These pulmotypes are the result of the so-called "enterotyping" analysis, a biostatistical method that makes it possible to stratify individuals according to the analysis of the microbiota. In the light of these data, it seems interesting to transcribe the concept of using a biomarker of the microbiota in the monitoring of a chronic lung disease such as asthma. The hypothesis is that there is respiratory dysbiosis causing corticosteroid resistance to treatment in children under 3 years of age with severe asthma.
Key Details
Gender
All
Age Range
1 Year - 3 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2022-02-04
Completion Date
2028-02-04
Last Updated
2024-09-23
Healthy Volunteers
No
Conditions
Interventions
Stool test
At inclusion (day 0), stools will be collected with a kit for to remove to 5 mg for each patient.
Blood test
Blood sample taken during inclusion (day 0) will be collected. There is between 19 and 26 mL for each patient.
Induced sputum
At inclusion (day 0), bronchial aspiration after inhalation induction of 4 mL of 6% salt serum administered (after 200 μg of salbutamol via an inhalation chamber during a bronchial drainage session).
nasale virology
At inclusion (Day 0), patients will be taken nasal swab for virology with swab adapted for nasal swab or with suction trap when blowing the child's nose (depending on center practice)and multiplex PCR.
Locations (1)
CHU de Brest
Brest, Finistère, France