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Clinical Efficacy of Megadose Vitamin C in Sepsis
Sponsor: Zhujiang Hospital
Summary
In this multicenter, randomized, single-blind, placebo-controlled clinical trial. Patients will be randomly assigned to receive Vitamin C or placebo for 4 days or until ICU discharge (whatever come first). The primary outcome is 28-day all-cause mortality.
Official title: Clinical Efficacy of Megadose Vitamin C in Sepsis (CEMVIS): A Multicenter, Randomized, Single-blind, Placebo-controlled Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
234
Start Date
2022-02-08
Completion Date
2024-12-25
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
Vitamin C
12 g vitamin C (48 ml) will be intravenously injected by a infusion pump every 12 h for 4 days or at ICU discharge
5% glucose injection
5% glucose solution 48 ml every 12 h for 4 days or at ICU discharge.
Locations (4)
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University
Guanzhou, Guangdong, China
Department of Critical Care Medicine of Yunfu People's Hospital
Yunfu, Guangdong, China
Department of Critical Care Medicine of Zhongshan People's Hospital
Zhongshan, Guangzhou, China
Department of Critical Care Medicine of Nanfang Hospital of Southern Medical University
Guanzhou, China