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TDCS to Improve Post-Stroke Cognitive Impairment
Sponsor: Johns Hopkins University
Summary
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention by individuals on the study team blinded to the participant's intervention. Participants will also undergo functional neuroimaging with magnetoencephalography (MEG) pre- and post-intervention (1, 3, and 6 months post-stroke to evaluate for initial and longer-term effects of treatment on cerebral activation patterns and functional connectivity). Neuroimaging and clinical outcomes will be assessed to determine the effect of tDCS versus sham + CCT on psMCI.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2022-09-01
Completion Date
2027-08-31
Last Updated
2025-09-16
Healthy Volunteers
No
Interventions
Anodal transcranial Direct Current Stimulation (A-tDCS)
Participants randomized to tDCS will undergo 5 weeks of A-tDCS + CCT.
Sham Intervention
Participants randomized to sham-intervention will undergo 5 weeks of sham + CCT.
Locations (1)
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States