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ACTIVE NOT RECRUITING
NCT05197426
PHASE2

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Best Supportive Care as Maintenance Therapy in Japanese Participants With Acute Myeloid Leukemia (AML) in Complete Remission

Sponsor: Bristol-Myers Squibb

View on ClinicalTrials.gov

Summary

The purpose of this study is to assess the efficacy and safety of oral azacitidine plus best supportive care versus best supportive care as maintenance therapy in a cohort of Japanese participants ≥ 55 years of age with Acute Myeloid Leukemia (AML) and in complete remission/complete remission with incomplete blood count recovery after conventional induction chemotherapy with or without consolidation chemotherapy.

Official title: A Phase 2, Randomized, Double-Blind, Placebo-controlled Study to Compare Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Best Supportive Care as Maintenance Therapy in Japanese Subjects With Acute Myeloid Leukemia in Complete Remission

Key Details

Gender

All

Age Range

55 Years - Any

Study Type

INTERVENTIONAL

Enrollment

19

Start Date

2022-01-17

Completion Date

2026-04-30

Last Updated

2026-02-11

Healthy Volunteers

No

Interventions

DRUG

Oral Azacitidine

Specified dose on specified days

OTHER

Placebo

Specified dose of specified days

Locations (31)

Local Institution - 0011

Huntsville, Alabama, United States

Local Institution - 0017

Nagoya, Aichi-ken, Japan

Local Institution - 0023

Nagoya, Aichi-ken, Japan

Local Institution - 0009

Toyoake, Aichi-ken, Japan

Local Institution - 0022

Aomori, Aomori, Japan

Local Institution - 0005

Kamogawa, Chiba, Japan

Local Institution - 0003

Kashiwa-shi, Chiba, Japan

Local Institution - 0010

Matsuyama, Ehime, Japan

Local Institution - 0020

Yoshida Gun, Fukui, Japan

Local Institution - 0016

Fukuoka, Fukuoka, Japan

Local Institution - 0014

Ōgaki, Gifu, Japan

Local Institution - 0001

Maebashi, Gunma, Japan

Local Institution - 0004

Sapporo, Hokkaido, Japan

Local Institution - 0019

Kanazawa, Ishikawa-ken, Japan

Local Institution - 0012

Isehara, Kanagawa, Japan

Local Institution - 0006

Sagamihara-shi, Kanagawa, Japan

Local Institution - 0013

Yokohama, Kanagawa, Japan

Local Institution - 0015

Sendai, Miyagi, Japan

Local Institution - 0026

Osaka, Osaka, Japan

Local Institution - 0021

Ōsaka-sayama, Osaka, Japan

Local Institution - 0031

Shimotsuke, Tochigi, Japan

Local Institution - 0032

Bunkyo Ku, Tokyo, Japan

Local Institution - 0002

Shinagawa, Tokyo, Japan

Local Institution - 0030

Shinjuku-ku, Tokyo, Japan

Local Institution - 0029

Sumida Ku, Tokyo, Japan

Local Institution - 0018

Fukuoka, Japan

Local Institution - 0027

Fukuoka, Japan

Local Institution - 0008

Nagasaki, Japan

Local Institution - 0025

Okayama, Japan

Local Institution - 0028

Saitama, Japan

Local Institution - 0007

Yamagata, Japan