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Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Summary
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.
Key Details
Gender
All
Age Range
8 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2018-12-04
Completion Date
2026-04-07
Last Updated
2025-05-02
Healthy Volunteers
Yes
Conditions
Interventions
MRI
Research unsedated MRI scans (outside of usual care) will be performed using a 3T Philips scanner at the F.M. Kirby Research Center. An MRI scanning protocol will be at the F.M. Kirby Research Center; the protocol will not last more than 1.5 hours. Acquisitions will include a triplanar survey, functional and anatomical multi-slice imaging of the brain as well as MRI of selected spinal levels. Protocols will be used that do not involve use of contrast agents and limit power/tissue absorption as well as otherwise remain within FDA and Kirby Center safety regulations. When possible, MRI will be performed within 3 months of initial survey/interview administration. If MRI is scheduled \>3 months after initial survey/interview administration, a brief survey will be re-administered to screen for changes in pain/clinical status.
Locations (4)
F.M. Kirby Center
Baltimore, Maryland, United States
Mt. Washington Pediatric Hospital
Baltimore, Maryland, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Kennedy Krieger Institute
Baltimore, Maryland, United States