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6 Month Follow up Study on the Changes of Postural Stability in Parkinsonian Patients in Response to High Frequency TMS.
Sponsor: Cairo University
Summary
Postural instability is one of the cardinal signs in Parkinson's disease (PD). It represents one of the most disabling symptoms in the advanced stages of the disease. It is associated with frequent falls and loss of independence. The aim of the current study is to assess the long term efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) on improving postural instability in PD patients.
Official title: The Long Term Efficacy of High Frequency Repetitive Transcranial Magnetic Stimulation on Postural Stability in Parkinsonian Patients.
Key Details
Gender
MALE
Age Range
55 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-07-23
Completion Date
2026-02-18
Last Updated
2025-11-19
Healthy Volunteers
No
Conditions
Interventions
High Frequency Repetitive Transcranial Magnetic Stimulation
The High Frequency repetitive TMS will be delivered to the scalp over the primary motor cortex contralateral to the more affected side using a MAGSTIM rapid2 machine (Model P/N 3576-23-09, MAGSTIM Company LTD, UK) connected with a figure - of- eight shaped coil. Each patient will receive 12 sessions over four weeks. Position of the coil will be adjusted to find the optimal scalp position and the location of stimulation that will be marked to maintain consistency among sessions. The session will consist of 24 trains of 50 stimuli each delivered at five Hz. The procedure will be conducted with the patients in the ''On'' state (75 min. after medications)
Locations (1)
Faculty of Physical Therapy, Cairo University
Giza, Ad Doqi, Giza District, Giza Governorate, Egypt